Dr. Zamrini will review the landscape of clinical trials in Alzheimer's Disease and how clinical trials have transformed clinical care. He will discuss current challenges in clinical care and in research as well as future prospects.
Dr. Zamrini has led Clinical Trials involving Alzheimer’s disease and related disorders (ADRD) since 1988. He participated in the pivotal Tacrine trial and has been heavily engaged as PI/ CoI on multiple pharma and NIH-funded trials. He is currently Director of Neurology at Irvine Clinical Research and Adjunct Professor of Clinical Research & Leadership at George Washington University in DC. His recent work, in collaboration with Qing Zeng, PhD, a national expert on machine learning and natural language processing, involved extraction of unstructured data from medical records to help identify cases of dementia that may not have been coded or recognized in the care plan. Other recent projects have centered on: 1) cardiorespiratory fitness (CRF) where a direct, proportional, and inverse relationship was found with incident ADRD, and a relationship was identified with change in cardiorespiratory fitness over time, and 2) use of Large Language Models for improved identification of cognitive impairment in electronic medical records and the use of artificial intelligence to identify medications that may potentially be repurposed for ADRD. His work has been published in journals including Alzheimer's & Dementia, Journal of Alzheimer's Disease, Journal of Personalized Medicine, Journal of Clinical Medicine, and Medical Sciences.